THE EFFECT OF SYNTHETIC ADJUVANT ON THE FORMATION OF THE IMMUNE RESPONSE
2016
Savina, S.V. | Ivashchenko, S.V. | Skornyakov, V.M. | Murtaevа, V.S.
The paper contains experimental materials on the effects of synthetic adjuvants on the formation of the immune responses.Currently, the search continues for new effective vaccines based on polymeric compounds having immunostimulating properties (Petrov R. V. et al. 1986, V. Schijns,2000)An important condition in the development of certain carriers (adjuvants) is the creation of a drug capable of long-term is in the body, with its active immune system and no local and General negative reactions in the body (Volpin O. M.,1992, etc.).We carried out experiments to study the synthetic adjuvant (BP), the raw material which is polydiallyldimethyl chloride - PES.Conducted preclinical trials to study acute and chronic toxicity in laboratory animals showed no abnormalities in physiological and Toxicological parameters, i.e. its harmlessness.The results show positive effects of synthetic adjuvants on the formation of General immune responses in animals that allow it to be used as a filler in vaccines.
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