Screening of anti-obesity drugs, their analogues and prohibited ingredients in slimming foods
2016
Yun, J., Ministry of Food and Drug Safety, Cheongju, Republic of Korea | Choi, J., Ministry of Food and Drug Safety, Cheongju, Republic of Korea | Kwon, K., Ministry of Food and Drug Safety, Cheongju, Republic of Korea | Jo, C.H., Ministry of Food and Drug Safety, Cheongju, Republic of Korea
Globally, obesity has been recognized as a serious health problem. Recently, slimming foods for weight loss and maintenance were found to contain anti-obesity drugs, their analogues, and prohibited ingredients. To avoid inspections by the Government, structurally modified analogs have been continuously synthesized. For rapid determination of adulterated slimming products, we simultaneously analyzed 21 illegal compounds using liquid chromatography (LC) equipped with photo diode array, and LC coupled with tandem mass spectrometry. The validation of the method was performed with regard to selectivity, linearity, limit of detection, limit of quantification, precision, and accuracy. We purchased 128 samples from the Korean market and online sources in the year 2015. In 31 samples, 3 illegal compounds were detected as follows: 9.9-135.3 mg/g of sibutramine, 0.2-17.5 mg/g of yohimbine, and 1.8 mg/g of icariin. This simultaneous detection method might prove to be a simple and rapid analysis for monitoring illegal compounds in slimming foods.
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