Anti-inflammatory and anti-atopic effects of corn silk (Zea mays L.) ethanol extracts
2017
Kim, H.Y., National Institute of Crop Science, Rural Development Administration, Wanju, Republic of Korea | Lee, M.J., National Institute of Crop Science, Rural Development Administration, Wanju, Republic of Korea | Seo, W.D., National Institute of Crop Science, Rural Development Administration, Wanju, Republic of Korea | Choi, S.W., National Institute of Crop Science, Rural Development Administration, Wanju, Republic of Korea | Kim, S.L., National Institute of Crop Science, Rural Development Administration, Suwon, Republic of Korea | Jung, G.H., National Institute of Crop Science, Rural Development Administration, Suwon, Republic of Korea | Kang, H.J., National Institute of Crop Science, Rural Development Administration, Wanju, Republic of Korea
This study evaluates the ability of corn silk (Zea mays L.) extract to function as a natural anti-inflammatory and anti-atopic therapeutic agent. The anti-inflammatory effects of corn silk were evaluated by measuring the inhibitory activities of nitric oxide (NO) and production of tumor necrosis factor-alpha (TNF-alpha). Anti-atopic effects were assessed by measuring the repression of thymus and activation-regulated chemokine (TARC). These results indicated that NICS-1 (corn silk ethanol extract) and NICS-3 (high maysin corn silk ethanol extract) functioned as anti-inflammatory agents by downregulating LPS-induced NO and TNF-alpha. Additionally, two extracts showed weak repression of TARC expression levels in tumor necrosis factor TNF-alpha plus IFN-γ induced HaCaT cells, respectively. These results suggest that corn silk extracts have anti-inflammatory and anti-atopic activities, and thus have the potential to reduce and alleviate the symptoms associated with atopic dermatitis.
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