Association of the Genotypes of Single Nucleotide Polymorphism Marker rs81437607 with Capric Acid Contents in longissimus dorsi Muscle in Pigs
2016
Kim, S.G., National Institute of Animal Science, RDA, Jeju, Republic of Korea | Park, H.B., National Institute of Animal Science, RDA, Jeju, Republic of Korea | Kang, Y.J., National Institute of Animal Science, RDA, Jeju, Republic of Korea | Shin, H., National Institute of Animal Science, RDA, Jeju, Republic of Korea | Cho, S.R., National Institute of Animal Science, RDA, Republic of Korea | Lee, W.S., Jeju National University, Jeju, Republic of Korea | Han, S.H., Jeju National University, Jeju, Republic of Korea | Cho, I.C., National Institute of Animal Science, RDA, Jeju, Republic of Korea
This study tested the association between genotypes of the single nucleotide polymorphism (SNP) marker, rs81437607 and capric acid (FA_C10_0) compositions in longissimus dorsi muscle in pigs. Eighteen fatty acid (FA) compositions were measured in a total of 974 F2 animals among 1,106 F2 progeny produced between Landrace and Jeju Black Pig (JBP). Among FA compositions tested, we identified a cluster of highly significant SNPs for capric acid compositions on 58 Mb position of Sus scrofa chromosome 12 (SSC12) using genome-wide association study (GWAS) with F2 genotypes from SNP panel analysis. GWAS results showed that the rs81437607 was the highest trait-related SNP marker with capric acid levels. Three genotypes (C/C, C/T and T/T) of rs81437607 marker were found in F2 population by further pyrosequencing. Association analysis results showed the significant differences between rs81437607 genotypes and capric acid compositions (P0.05). The F2 pigs harboring rs81437607 C/C (0.119±0.002%) and C/T (0.116±0.002%) genotypes showed additively higher levels of capric acid content than those of T/T homozygotes (0.109±0.002%) (P
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