Anticholinesterase and Anti-inflammatory Constituents from Beilschmiedia pulverulenta Kosterm
2016
Salleh, W.M.N.H.W., Department of Chemistry, Faculty of Science, University, Teknologi Malaysia (UTM), Johor, Malaysia | Ahmad, F., Department of Chemistry, Faculty of Science, University, Teknologi Malaysia (UTM), Johor, Malaysia | Yen, K.H., University Teknologi MARA (UiTM) Sarawak Jalan Meranek, Sarawak, Malaysia | Zulkifli, R.M., University Teknologi Malaysia (UTM), Johor, Malaysia
Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), beta-sitosterol (8), and beta-sitostenone (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 - 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC50 values ranging from 168.8 - 504.2 μM and 21.0 - 59.4 μM, respectively.
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