Monokomponentni dijetetski suplementi folne kiseline na tržištu Republike Srbije – farmaceutskotehnološka ispitivanja i karakteristike / Monocomponent folic acid dietary supplements marketed in Serbia – pharmaceutical technical investigation and character
2015
Čalija, Bojan (Farmaceutski fakultet, Beograd (Srbija). Katedra za farmaceutsku tehnologiju i | Kozmetologiju) | Đuriš, Jelena (Farmaceutski fakultet, Beograd (Srbija). Katedra za farmaceutsku tehnologiju i | Kozmetologiju) | Dobričić, Vladimir (Farmaceutski fakultet, Beograd (Srbija). Katedra za farmaceutsku hemiju) | Vidović, Bojana (Farmaceutski fakultet, Beograd (Srbija). Katedra za bromatologiju) | Milić, Jela (Farmaceutski fakultet, Beograd (Srbija). Katedra za farmaceutsku tehnologiju i | Kozmetologiju) | Šobajić, Slađana (Farmaceutski fakultet, Beograd (Srbija). Katedra za bromatologiju)
Introduction. Disintegration of the solid dosage form of dietary supplements and folic acid dissolution rate are of particular importance for its bioavailability. However, current legislation in the Republic of Serbia does not set criteria for the pharmaceutical technical quality of dietary supplements. The United States Pharmacopoeia, on the other hand, gives testing standards for disintegration, dissolution and weight variation of dietary supplements. Aim. The objective of this study was to investigate and compare pharmaceutical technical quality of solid dosage forms of dietary supplements marketed in Serbia, with regard to the United States Pharmacopoeia standards for dietary supplements and European Pharmacopoeia standards for solid dosage forms of pharmaceutical preparations. Methods. Seven monocomponent folic acid dietary supplements commercially available in Serbia, from which three uncoated tablets, three coated tablets and one hard capsules, were subjected, depending on the dosage form, to the weight variation, friability, hardness, disintegration and dissolution testing. Conclusion. The obtained results have shown that six out of seven investigated products complies with United States Pharmacopoeia standards for pharmaceutical technical quality of dietary supplements, while only one (hard capsules) failed to meet the requirements for disintegration.
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