Current status and prospects of the meiosis-specific function of recombinase in plants
2018
Jung, Y.J., Hankyong National University, Anseong, Republic of Korea | Nam, K.H., Hankyong National University, Anseong, Republic of Korea | Kim, T.S., Korea National Open University, Seoul, Republic of Korea | Lee, I.H., National Institute of Biological Resources, Incheon, Republic of Korea | Cho, Y.G., Chungbuk National University, Cheongju, Republic of Korea | Kang, K.K., Hankyong National University, Anseong, Republic of Korea
Meiosis is a specialized cell division, essential in most reproducing organisms to halve the number of chromosomes, thereby enabling the restoration of ploidy levels during fertilization. A key step in meiosis is homologous recombination, which promotes homologous pairing and generates crossovers (COs) to connect homologous chromosomes until their separation at anaphase I. These CO sites, seen cytologically as chiasmata, represent a reciprocal exchange of genetic information between two homologous non-sister chromatids. RAD51, the eukaryotic homolog of the bacterial RecA recombinase, plays a central role in homologous recombination (HR) in yeast and animals. Loss of RAD51 function causes lethality in the flowering plant, Arabidopsis thaliana, suggesting that RAD51 has a meiotic stage-specific function that is different from homologous pairing activity.
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