Sub-chronic toxicity study in rats orally exposed to nanostructured silica
2014
Zande, van der, M. | Vandebriel, R.J. | Groot, M.J. | Kramer, E.H.M. | Herrera Riviera, Z.E. | Rasmussen, K. | Ossenkoppele, J.S. | Tromp, P. | Gremmer, E.R. | Peters, R.J.B. | Hendriksen, P.J. | Marvin, H.J.P. | Hoogenboom, L.A.P. | Peijnenburg, A.A.C.M. | Bouwmeester, H.
Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.
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