Preliminary assessment of antioxidative properties of glutarimide derivatives
2019
Popović-Đorđević, Jelena (https://orcid.org/0000-0003-4057-3826) | Kozarski, Maja (https://orcid.org/0000-0002-3576-5551) | Klaus, Anita (https://orcid.org/0000-0001-5073-3702) | Banjac, Nebojša
Preventing or slowing down the formation of oxidative stress, that occurs as a result of increasing amounts of free radicals in the body, is a major task for drug development. Glutarimide derivatives were examined for radical scavenging activities. The study revealed that the compounds tested showed no scavenging ability of 2,2-diphenyl-1-picrylhydrazyl DPPH radical in the examined concentration range (0.05–3.00 mg/mL), except for compound 4 (2,6-dioxo-1-phenethyl-piperidine-3carboxylic acid 1,1-dimethyl-propyl ester), which showed very weak activity (2.3– 5.7%) compared to 2,6-bis(1,1-dimethylethyl)-4-methylphenol (BHT), ascorbic acid, αtocopherol and catechin used as standards. These results indicate the need for designing the structural analogs of glutarimide 4, with diverse substituents in order to improve radical scavenging activity of these compounds.
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