Lühiartikkel: PGF2α ja parenteraalselt manustatava tseftofuuri kasutamine poegimisjärgsete emakapõletike ravis lüpsilehmadel

Present study was designed to get additional knowledgeabout treatment of postpartum (PP) clinical metritis (CM) and clinicalendometritis (CE), using combination of systemic antibiotics withadministration of prostaglandin F2α (PGF2α), to determine the optimaltime of treatment, to study effect of this treatment on clinical,physiological and fertility parameters.Late pregnant dairy cows with diagnosed CM and CE were divided to theexperimental and positive control groups and negative control groups werecomposed of healthy cows. Measurements of body temperature, examinationof general health status and vaginal discharge, bacteriological andcytological examinations, determination of plasma or milk progesterone,measuring of acute phase proteins and data of fertility parameters wereused for evaluation of treatment success. Using of combination of systemicadministrations of ceftiofur with two injections of PGF2α at intervals of 8h was compared with using of combination of intramuscular administrationof ceftiofur with flunixin. Treatment of CE using systemic administrationsof ceftiofur with two injections of PGF2α with an interval of 8h in the early PP (5–10 day after calving) was compared with treatment inthe late PP (30–35 day PP). The findings of the present study indicate thattreatment of CM and CE using flunixin in addition to parenteral antibioticdid not improve clinical cure, inflammatory parameters or elimination ofbacteria from the uterus. Regardless of more severe inflammation that wasdetected in animals from the group treated by parenteral administration ofantibiotic with PGF2α they showed the same fertility parameters ashealthy animals. Results of this study suggests that treatment of CE in theearly PP period, using systemic administration of ceftiofur with twoinjections of PGF2α at an interval of 8 h, could be more preferable to usingthe same treatment in the late PP.