A new latent lovastatin producer viz. Fusarium pseudocircinatum IBRL B3-4, produced in laboratory tray system
2014
Darah, I. | Syarifah, A. R. | I Nyoman, P. A.
A proximate analysis study of local rice bran and brown rice disclosed a distinguish level of chemical compositions. Lipid, carbohydrate and ash occupy in rice bran, while fibre is a predominant component in brown rice. Both perceptible anti-cholesterol substrates were grown with locally isolated Fusarium pseudocircinatum IBRL B3-4 to obtain the best lovastatin activity via dichloromethane extraction. Evaluation of lovastatin production at different substrate thickness ranges of 0.25 to 1.5 cm in a static tray system (20x20x6 cm3) exposed the highest production at 0.5 cm level (1135.0±6.7 μg/g dry solid of lovastatin). Meanwhile, effects of physical parameters investigation interpreted that the original substrate size, 60% (v/w) moisture content and ambient local temperature of 30±2°C as the most suitable conditions to generate lovastatin at the utmost level. Meanwhile, the maximum production was synthesized at day 12th (twelfth) under solid substrate fermentation system. A significant activity increment was revealed after 60 % (v/v) moisture content had been applied into tray system. In more specific, it boosted up to 2271.7±14.4μg/g dry solid of lovastatin.
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