An integration-free iPSC line ZZUNEUi008-A derived from dermal fibroblasts of a child with cardiac valvular dysplasia carrying a mutation in FLNA gene
2020
Xiaowei Li | Yanyu Lu | Jiaxiang Wang | Mengduan Liu | Mengyu Wang | Liang Hu | Wenting Du | Lu Wang | Zhengming Jiang | Xiangmei Gu | Zhongren Ding | Deguang Feng | Ling Li | Jianzeng Dong | Xiaoyan Zhao
FLNA gene encodes an actin-binding protein filamin A and mutations in FLNA can causes X-Linked cardiac valvular dysplasia. In this study, we report the generation of ZZUNEUi008-A, a human induced pluripotent stem cell line from a 10-year-old male patient with c. 84G → A in FLNA gene using non-integrative Sendai viral reprogramming technology. The ZZUNEUi008-A iPSC line expresses pluripotency markers, exhibits a normal male karyotype (46, XY) and can differentiate into three germ layers in vivo.
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