Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery
2019
Bo Sang Kim | Yi-Ting Chen | Pannaree Srinoi | Maria D. Marquez | T. Randall Lee
A “smart” core@shell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (m-) silica layer (m-SiO<sub>2</sub>). The GNS@m-SiO<sub>2</sub> nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a m-SiO<sub>2</sub> layer providing additional non-collapsible space for drug storage. The influence of the m-SiO<sub>2</sub> layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a m-SiO<sub>2</sub> layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no m-SiO<sub>2</sub> shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation.
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