Addressing the challenges of natural products drug discovery
2010
Mustafa A. M. | Tan, S. | Hadi, A. H. A. | Appleton, D.R. | Mustafa M. R. | Buss, A. D.
Natural products research has a clear role to play in the discovery of new pharmaceuticals with around 50% of marketed drugs being derived from natural sources. After a significant scaling back of natural products research by large pharma in the 1990's, it is this continuing trend that led to a revival of interest in the past 5-8 years. Despite this renewed interest in natural products drug discovery, there are still not many success stories. However, natural products research clearly has a place in the world within pharmaceutical research and, more widely in other fields such as nutraceuticals and agrochemicals. We must continually develop new tools and technologies to address the challenges of natural products research and look for ways to use them outside of traditional drug discovery activities. Chemical Fingerprinting of natural products extracts, prefractionation and LCMS dereplication-biological profiling are such tools that improve the natural products drug discovery process and can also be applied in many other areas. Examples of these tools and their applications along with discussion on the future of natural products research will be presented.
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