Detection of plasmid mediated colistin resistant (mcr-1) gene in Salmonella spp. isolated from chicken
2020
Siti Norhanani R. | Khoo, E. | Nafizah M. | Normah M. A. | Roseliza R. | Nurul Syafiqah Z. | Mohammad Fhitri S. | Faizah Hanim M. S.
The emergence of multidrug resistant (MDR) microbes is a major threat worldwide, and it has become worse with the emergence of resistance towards colistin antibiotic. Presence of plasmid mediated colistin resistant gene (mcr-1) in bacteria contributes much to the spread of colistin resistant among Enterobacteriaceae such as Escherichia.coli and Salmonella spp. Since the first description of mcr-1 gene in E. coli from livestock in 2015, numerous reports had revealed a worldwide spread of mcr-1 gene among foodborne pathogen. In Malaysia, there is a lack of data on detection of mcr-1 gene among Salmonella strains in food producing animals. Hence, this paper focuses on the detection of mcr-1 gene in Salmonella spp. isolated from chickens submitted to the Veterinary Research Institute (VRI) using published primers. A total of 284 salmonella isolates retrieved from monitoring and surveillance cases submitted to VRI from year 2016 and 2017 were used in this study. 3.17% (9/284) of the isolates were found to carry the mcr-1 gene. This finding supports the existence of mcr-1 gene in Salmonella spp. from chickens in the country. Antimicrobial resistance problems become complex when the bacterial strain carrying mcr-1 gene become highly resistant to colistin, the last choice of antibiotic mainly used for the treatment against Gram-negative bacterial infection both in human and animals. Inter-agency collaboration to gather baseline data on colistin usage is crucial to assess the issue and help draw guidelines to reduce the impact of colistin resistance in Malaysia
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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تم تزويد هذا السجل من قبل Universiti Putra Malaysia
