Listeriosis in sheep: experimental listeric infection in sheep treated with various immunosuppressiva [Listeria monocytogenes, prednisolone, cyclophosphamide, niridazole, gestagene hormones, immunity, blood components]
1980
Groenstoel, H. (State Veterinary Research Station for Small Ruminants, Hoeyland, Sandnes (Norway))
Four groups of lambs, about 6 months old, were given 4 different immunosuppressiva (prednisolone, cyclophosphamide, niridazole and gestagene hormones), 1 substnace to each group. After this treatment the 4 groups together with a 5th group of the same size, were infected with Listeria monocytogenes (Lm). None of the animlas developed clinical listeric encephalitis. The level of antibodies differed between the groups. The group not given any immunosuppressivum reached the highest antibody titres, the group given gestagene hormones had the lowest titres and the other groups ranged somewhere in between. All the groups except the group treated with niridazole had a strong delayed hypersensitivity reaction against Lm. The effects of the treatment upon some blood components are also described. Further studies are necessary to establish the effect of various immunosuppressiva, especially gestagene hormones
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