Selenium concentrations in tissues of sheep given a subcutaneous injection of barium selenate or sodium selenate
1994
Archer, J.A. (Adelaide Univ., Glen Osmond (Australia). Dept. of Animal Science) | Judson, G.J. (South Australian Dept. of Primary Industries, Adelaide. Central Veterinary Lab.)
Young sheep were allocated to 6 treatment groups, each of 8 ewes and 8 wethers. Treatments given were nil, 0.1, or 0.5 mg Se per kg body weight as a subcutaneous injection of sodium selenate (Na2SeO4), and 0.8, 1.4, or 2.9 mg Se per kg body weight as a subcutaneous injection of barium selenate (BaSeO4). In sheep given Na2SeO4 there was a rapid but transient increase in the mean Se concentration in tissues, particularly the liver of sheep given the highest dose of Na3SeO4. In these sheep on days 14, 28, 56, and 112 the respective mean liver concentrations were 169, 62, 25, and 6.9 micromol per kg DM: the mean value on day 14 was 15 times the mean value in untreated sheep. In sheep given BaSeO4 there was a gradual increase in mean Se concentration of tissues during the experiment. The results indicate that the BaSeO4 doses were unlikely to cause Se toxicity in young sheep or result in Se residues in tissues above those recommended for human consumption. The BaSeO4 should be administered subcutaneously in the neck or other sites of the body not sold for human consumption.
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