Why should we need the gut microbiota to respond to cancer therapies?
2014
Viaud, Sophie | Daillere, Romain | Yamazaki, Takahiro | Lepage, Patricia | Boneca, Ivo | Goldszmid, Romina | Trinchieri, Giorgio | Zitvogel, Laurence
Cyclophosphamide, one of the most efficient tumoricidal, antiangiogenic, and immunostimulatory drugs employed to date mediates part of its effects through intestinal bacteria, against which the host becomes immunized during treatment. Our recent work suggests that anti-commensal effector pT(H)17 and memory T(H)1 CD4(+) T-cell responses are indispensable for optimal anticancer effects as mediated by cyclophosphamide.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique