Chemical composition and antibacterial activity of bee venom against multi-drug resistant pathogens

Gökmen, Tülin G.; Yazgan, Hatice; Özdemir, Yıldız; Sevin, Sedat; Turut, Nevin; Karahan, Şifa; Eşki, Funda; Kıvra, İbrahim; Sezer, Osman; Ütük, Armağan E

Chemical composition and antibacterial activity of bee venom against multi-drug resistant pathogens

2023

Gökmen, Tülin G.(Cukurova University Ceyhan Veterinary Faculty Department of Microbiology) | Yazgan, Hatice(Cukurova University Ceyhan Veterinary Faculty Department of Food Hygiene and Technology) | Özdemir, Yıldız(Adana City Hospital Microbiology Laboratory) | Sevin, Sedat(Ankara University Veterinary Faculty Department of Pharmacology and Toxicology) | Turut, Nevin(Veterinary Control Institute Microbiology Laboratory) | Karahan, Şifa(Veterinary Control Institute Microbiology Laboratory) | Eşki, Funda(Cukurova University Veterinary Faculty Department of Obstetrics and Gynecology) | Kıvra, İbrahim(Koçman University Mugla Vocational School Department of Chemistry and Chemical Processing Technologies) | Sezer, Osman(Veterinary Control Institute Parasitology Laboratory) | Ütük, Armağan E(Cukurova University Ceyhan Veterinary Faculty Department of Parasitology)

Bee venom with an antimicrobial effect is a powerful natural product. One of the most important areas where new antimicrobials are needed is in the prevention and control of multi-drug resistant pathogens. Today, antibacterial products used to treat multi-drug resistant pathogen infections in hospitals and healthcare facilities are insufficient to prevent colonisation and spread, and new products are needed. The aim of the study is to investigate the antibacterial effect of the bee venom (BV), a natural substance, on the species of Methicillin resistant Staphylococcus aureus, Vancomycin resistant Enterococcus faecalis, Carbapenem resistant Escherichia coli, Carbapenem resistant Klebsiella pneumoniae and Carbapenem resistant Acinetobacter baumannii. As a result of this study, it was found that MIC90 and MBC90 values ranged from 6.25 μg/mL - 12.5 μg/mL and numbers of bacteria decreased by 4-6 logs within 1-24 h for multi-drug resistant pathogens. In particular, Vancomycin resistant Enterococcus faecalis isolate decreased 6 log cfu/mL at 50 μg/mL and 100 μg/mL concentrations in the first hour. The effective bacterial inhibition rate of bee venom suggests that it could be a potential antibacterial agent for multi-drug resistant pathogens. CONTRIBUTION: The treatment options of antibiotic-resistant pathogens are a major problem in both veterinary and human medicine fields. We have detected a high antibacterial effect against these agents in this bee venom study, which is a natural product. Apitherapy is a fashionable treatment method all over the world and is used in many areas of health. Bee venom is also a product that can be used as a drug or disinfectant raw material and can fill the natural product gap that can be used against resistant bacteria.

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