Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases

Masanari Kuwabara; Tomoko Fukuuchi; Yuhei Aoki; Einosuke Mizuta; Motoshi Ouchi; Masafumi Kurajoh; Tatsuya Maruhashi; Atsushi Tanaka; Nagisa Morikawa; Kensuke Nishimiya; Naoyuki Akashi; Yoshihiro Tanaka; Naoyuki Otani; Mihoko Morita; Hiroshi Miyata; Tappei Takada; Hiroshi Tsutani; Kazuhide Ogino; Kimiyoshi Ichida; Ichiro Hisatome; Kohtaro Abe

Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases

2023

The prevalence of patients with hyperuricemia or gout is increasing worldwide. Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and/or fructose intake, and physical activity. While numerous studies have reported various comorbidities linked to hyperuricemia or gout, the range of these associations is extensive. This review article focuses on the relationship between uric acid and thirteen specific domains: transporters, genetic factors, diet, lifestyle, gout, diabetes mellitus, metabolic syndrome, atherosclerosis, hypertension, kidney diseases, cardiovascular diseases, neurological diseases, and malignancies. The present article provides a comprehensive review of recent developments in these areas, compiled by experts from the Young Committee of the Japanese Society of Gout and Uric and Nucleic Acids. The consolidated summary serves to enhance the global comprehension of uric acid-related matters.

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