Serum Biochemical Changes in Response to Affection with Pseudomonas aeruginosa Mastitis in Holstein Dairy Cows
2023
Dina R.S. Gad El-Karim | Gamal A. El-Amrawi | Alyaa R. Salama
Despite of the great efforts to develop effective control programs for mastitis, it is still one of the most economically important diseases in dairy cattle herds. Pseudomonas aeruginosa is a member of coliform Gram-negative bacteria causing treatment-resistant clinical or sub-clinical mastitis in dairy cows. This study aimed to evaluate the influence of affection with clinical P. aeruginosa mastitis on some oxidative stress biomarkers, inflammatory cytokines and proteins, in addition to some complement factors in Holstein dairy cows. Affection with P. aeruginosa mastitis evoked a state of oxidative stress which accompanied with depletion of cellular enzymatic and non-enzymatic anti-oxidants and elevation of lipid peroxide and advanced oxidation protein product (AOPP) level. Additionally, this affection stimulated the release of some inflammatory cytokines and proteins, enhanced activity of caspase-1. In contrary, the level of complement factor 2 (C2), complement fragments C3b and complement fragment C5a has been decreased upon affection with mastitis. In conclusion, marked oxidative stress state and enhanced release of inflammatory cytokines and proteins with complement system defective activation may share in pathogenesis and virulence of P. aeruginosa-induced clinical mastitis in dairy cattle.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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