Fasting plasma carotenoids concentrations in Crohn’s and pancreatic cancer patients compared to control subjects
2009
Drai, J. | Borel, Patrick | Faure, H. | Galabert, C. | Le Moël, G. | Laromiguière, M. | Fayol, V. | Centre Hospitalier Universitaire de Lyon | Nutriments Lipidiques et Prévention des Maladies Métaboliques ; Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Département de biologie intégrée ; CHU Grenoble-Hôpital Michallon | Hôpital Renée Sabran ; Partenaires INRAE | French Society for Vitamins and Biofactors ; Partenaires INRAE | Hôpital Hôtel-Dieu [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Laboratoire Analyses Médicale ; Partenaires INRAE
International audience
اظهر المزيد [+] اقل [-]إنجليزي. Carotenoids are colored molecules that are widespread in the plant kingdom, but animals cannot synthesize them. Carotenes are long, apolar molecules which require fully functioning digestive processes to be absorbed properly. Hence they could be interesting markers of intestinal absorption and digestion. Indeed, only few tests are available to assess these processes and only the D-xylose tolerance test is routinely used. However D-xylose is a sugar that tests only the absorption of water-soluble compounds and it only tests duodenal absorption. In this study, we have evaluated carotenoids as markers of digestion and absorption. We compared fasting plasma carotenoids concentrations in 21 control subjects, 20 patients with Crohn’s disease, and 18 patients with pancreatic cancer. Crohn’s disease alters intestinal absorption while pancreatic cancer decreases pancreatic enzyme secretion thus impairing digestion. Results show that all carotenoids are significantly lower in Crohn’s and cancer patients as compared to control subjects and the multifactorial analysis shows that this decrease is mostly independent of dietary intake. Interestingly, maldigestion as seen in pancreatic cancer more strongly influences plasma lutein and lycopene concentrations while malabsorption in Crohn’s disease acts on other carotenoids. Thus carotenoids could be interesting alternatives for testing and following patients that are suspected of having malabsorption or maldigestion syndromes
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Institut national de la recherche agronomique