Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug
2021
Kaliyamoorthi, Kiruthiga | Sumohan Pillai, Archana | Alexander, Aleyamma | Ramasamy, Sivaraj | Arivarasu, Anitha | Enoch, Israel V. M. V.
Magnetic drug carriers are aimed at transporting the loaded drugs to the target site with the application of an external field. To realize this, a clever design of magnetic nanoparticles and their surface modification have to be achieved. Herein, we report the synthesis of ErFeO₃ nanoparticles and their magnetic characteristics. In addition, we report a β-cyclodextrin-polyethylene glycol-folate conjugate and utilize it for coating the magnetic nanoparticles. The crystallinity and grain size of the nanoparticles are characterized using X-ray diffraction. The elemental composition of the nanoparticles and their orbital states are determined using XPS spectroscopy. The polymer-coated nanoparticles are soft ferromagnetic. The anticancer drug, camptothecin, is loaded on the polymer-coated nanoparticles with a loading percentage of about 88%. The efficacy of camptothecin gets enhanced when loaded on the magnetic nanocarrier and released in a sustained manner. Compared to the free form, the drug loaded on the nanocarrier shows an enhanced anticancer activity.
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