Bombyxin-related peptides: cDNA structure and expression in the brain of the hornworm Agrius convolvuli
1996
Iwami, M. | Furuya, I. | Kataoka, H.
We have cloned three cDNAs from the sweet potato hornworm Agrius convolvuli that encode precursor molecules for peptides structurally related to bombyxin, an insulin-related brain secretory peptide in Bombyx mori. The Agrius bombyxin-related peptide (ABRP) cDNAs are classified into type A and B according to their sequence similarity. The prepro-ABRPs deduced from the cDNA sequences have the insulin-like domain organization of signal peptide/B chain/C peptide/A chain. The ABRP transcripts in Agrius brain were shown to locate in four pairs of medial neurosecretory cells, the homologous group of neurosecretory cells that produce bombyxins in Bombyx brain. Genomic Southern analysis indicated the presence of multiple copies of ABRP gene in the Agrius genome. Results showed that the ABRP genes are remarkably different from the vertebrate insulin genes in the number of copy and spatial localization of the transcripts.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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