Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4⁺T Cells into the Th2 or Th1 Phenotype
2012
NAKAJIMA-ADACHI, Haruyo | Koike, Emiko-Rose | TOTSUKA, Mamoru | HIRAIDE, Erika | WAKATSUKI, Yoshio | Kiyono, H. (Hiroshi) | Hachimura, S. (Satoshi)
The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.
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