Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting

Gulson, Brian; Mizon, Karen; Taylor, Alan; Korsch, Michael; Davis, J Michael; Louie, Honway; Wu, Michael; Gómez, Laura; Antin, Luminita

Pathways of Pb and Mn observed in a 5-year longitudinal investigation in young children and environmental measures from an urban setting

2014

We monitored 108 children ≤5 years on a 6-month basis for up to 5 years in a major urban setting. Samples (n ∼ 7000) included blood, urine, handwipes (interior, and after exterior playing), 6-day duplicate diet, drinking water, interior house and day care dust-fall accumulation using petri dishes, exterior dust-fall accumulation, exterior dust sweepings, paint, soil and urban air. The geometric mean blood Pb (PbB) was 2.1 μg/dL and blood Mn (MnB) was 10.0 μg/L. Following a path modelling approach, mixed model analyses for a fully adjusted model showed the strongest associations for PbB were with interior house dust and soil; for MnB there were no significant associations with any predictors. Predictor variables only explained 9% of the variance for Pb and 0.7% for Mn. Relationships between environmental measures and PbB in children are not straightforward; soil and dust sweepings contribute only about 1/5th of the amounts to PbB found in other studies.

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