Vitamin E, antioxidants and lipid peroxidation in experimental atherosclerosis of rabbits
1978
Wilson, Robert | Middleton, Charles C. | Sun, Grace Y.
Extract: The effects of large amounts of dietary vitamin E and butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were evaluated in rabbits fed a low-cholesterol, atherogenic diet. Rabbits were fed a purified atherogenic diet, containing butter or the basal diet supplemented with either 1.0 percent of vitamin E or 0.1 percent each of BHA and BHT for periods up to 3 years. A negative control group was fed the basal diet with corn oil replacing butter. Aortic and coronary atherosclerosis were more frequent and extensive in rabbits fed either the basal diet or the basal diet supplemented with BHA and BHT than in rabbits fed either the basal diet supplemented with vitamin E or the negative control diet. Dietary vitamin E inhibited atherogenesis by preventing hypercholesterolemia. No evidence of lipid peroxidation was detected in the arterial lesions.
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