Dependence of the effects of dietary cholesterol and experimental conditions on serum lipids in man. I. Effects of dietary cholesterol in a linoleic acid-rich diet
1979
Bronsgeest-Schoute, Driek C. | Hautvast, Joseph G.A.J. | Hermus, Ruud J.J.
Although correlation between dietary cholesterol intake and blood cholesterol levels is lacking, most diet and heart disease recommendations suggest limitation of dietary cholesterol, reduction of saturated fat, and increase of linoleic acid intake. For 1 week, 41 males and females aged 19 to 35 ate a diet with 14 to 15 energy % linoleic acid. Then for 2 weeks, 1 group of subjects ate at least 600 mg cholesterol a day mainly from egg yolk, another less than 200 mg. Both groups continued the amount of linoleic acid. Subsequently, the groups reversed diets for another 2 weeks. Serum cholesterol increased significantly after the high-cholesterol diet. The effect on serum triglycerides was unclear, but the mean difference between groups indicated a sequence effect. An 11 mg/100 ml difference in serum cholesterol level resulted from a 656 mg/ml difference in dietary cholesterol intake. Thus, the high linoleic acid content seems to reduce the impact of dietary cholesterol in the form of egg yolk on serum cholesterol.
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