Intrathalamic connections shape spindle activity – a modelling study
2018
Bús, Bálint | Antal, Károly | Emri, Zsuzsa
Spindle oscillations are generated predominantly during sleep state II, through cyclical interactions between thalamocortical and reticular neurons. Inhibition from reticular cells is critical for this activity; it enables burst firing by the de-inactivation of T-type Ca²⁺ channels. While the effect of different channelopathies on spindling is extensively investigated, our knowledge about the role of intrathalamic connections is limited. Therefore, we explored how the connection pattern and the density of reticular inhibitory synapses affect spindle activity in a thalamic network model. With more intrareticular connections, synchronous firing of reticular cells, and intraspindle burst frequency decreased, spindles lengthened. In models with strong intrareticular inhibition spindle activity was impaired, and a sustained 6–8 Hz oscillation was generated instead. The strength of reticular innervation onto thalamocortical cells played a key role in the generation of oscillations; it determined the amount of thalamocortical cell bursts, and consequently spindle length. Focal inputs supported bursts but affected only a few cells thus barely reinforced network activity, while diffuse contacts aided bursts only when a sufficient number of reticular cells fired synchronously. According to our study, alterations in the connection pattern influence thalamic activities and may contribute to pathological conditions, or alternatively, they serve as a compensatory mechanism.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل National Agricultural Library
