Advances in Chromatin and Chromosome Research: Perspectives from Multiple Fields
2020
Agbleke, Andrews Akwasi | Amitai, Assaf | Buenrostro, Jason D. | Chakrabarti, Aditi | Chu, Lingluo | Hansen, Anders S. | Koenig, Kristen M. | Labade, Ajay S. | Liu, Sirui | Nozaki, Tadasu | Ovchinnikov, Sergey | Seeber, Andrew | Shaban, Haitham A. | Spille, Jan-Hendrik | Stephens, Andrew D. | Su, Jun-Han | Wadduwage, Dushan
Nucleosomes package genomic DNA into chromatin. By regulating DNA access for transcription, replication, DNA repair, and epigenetic modification, chromatin forms the nexus of most nuclear processes. In addition, dynamic organization of chromatin underlies both regulation of gene expression and evolution of chromosomes into individualized sister objects, which can segregate cleanly to different daughter cells at anaphase. This collaborative review shines a spotlight on technologies that will be crucial to interrogate key questions in chromatin and chromosome biology including state-of-the-art microscopy techniques, tools to physically manipulate chromatin, single-cell methods to measure chromatin accessibility, computational imaging with neural networks and analytical tools to interpret chromatin structure and dynamics. In addition, this review provides perspectives on how these tools can be applied to specific research fields such as genome stability and developmental biology and to test concepts such as phase separation of chromatin.
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