No vitamin-C benefit found in Ca trial
1979
The Mayo Clinic rigorously controlled a clinical trial of high-dose ascorbic acid with terminal cancer patients. Sixty Mayo patients with untreatable solid tumors received 10g of ascorbic acid per day; 63 others received a placebo. Dr. Edward T. Creagan of the Clinic reported that no therapeutic benefit was identified for those patients receiving ascorbic acid. Survival cures for both groups completely overlapped with no differences in appetite, activity level, or pain complaints. The Mayo study was supported by Dr. Stephen H. Rosenoff's study which treated patients with 40g per day with no improvement. The studies were prompted by a 1976 research report by Dr. Linus Pauling which postulated that vitamin C has a number of anticancer properties, notably the enhancement of the body's immune resistance and cancer-cell surveillance. Dr. Pauling suggested that differences in the studies' findings could be attributed to earlier chemotherapy that compromised the immune response.
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