Adsorption of various antimicrobial agents to endotoxin removal polymyxin-B immobilized fiber (Toraymyxin®). Part 2: Adsorption of two drugs to Toraymyxin PMX-20R cartridges

Shimokawa, Ken-ichi; Takakuwa, Ryotaro; Wada, Yūko; Yamazaki, Noriko; Ishii, Fumiyoshi

Adsorption of various antimicrobial agents to endotoxin removal polymyxin-B immobilized fiber (Toraymyxin®). Part 2: Adsorption of two drugs to Toraymyxin PMX-20R cartridges

2013

Shimokawa, Ken-ichi | Takakuwa, Ryotaro | Wada, Yūko | Yamazaki, Noriko | Ishii, Fumiyoshi

In our previous study, the degree of adsorption of 9 representative antimicrobial agents to Toraymyxin® PMX-F sheets was quantitatively evaluated [1]. As a result, the adsorption rate was 22.1% for Linezolid in the presence of serum.Therefore, we investigated whether two types of antimicrobial agents (Ciprofroxacin and Linezolid) can be better adsorbed on PMX-F sheets. When the number of PMX-F sheets was increased in a step wise manner, specifically 2, 4, 6, 8 and 12, the adsorption rate increased linearly.In addition, the adsorption to polymyxin-B immobilized fiber (Toraymyxin® PMX-20R) cartridges, widely used to remove endotoxins from circulating blood in the treatment of sepsis, was quantitatively evaluated. As a result, in the presence of serum, Linezolid showed adsorption to PMX-20R, and the adsorption rate after 2h was 54.5%, and that after 4h was 65.8%.The results of this study suggest the necessity of monitoring blood antimicrobial concentration during treatment for sepsis with Linezolid, which showed adsorption to PMX-20R in an environment close to a clinical environment.

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