Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
2021
Supasa, Piyada | Zhou, Daming | Dejnirattisai, Wanwisa | Liu, Chang | Mentzer, Alexander J. | Ginn, Helen M. | Zhao, Yuguang | Duyvesteyn, Helen M.E. | Nutalai, Rungtiwa | Tuekprakhon, Aekkachai | Wang, Beibei | Paesen, Guido C. | Slon-Campos, Jose | López-Camacho, César | Hallis, Bassam | Coombes, Naomi | Bewley, Kevin R. | Charlton, Sue | Walter, Thomas S. | Barnes, Eleanor | Dunachie, Susanna J. | Skelly, Donal | Lumley, Sheila F. | Baker, Natalie | Shaik, Imam | Humphries, Holly E. | Godwin, Kerry | Gent, Nick | Sienkiewicz, Alex | Dold, Christina | Levin, Robert | Dong, Tao | Pollard, Andrew J. | Knight, Julian C. | Klenerman, Paul | Crook, Derrick | Lambe, Teresa | Clutterbuck, Elizabeth | Bibi, Sagida | Flaxman, Amy | Bittaye, Mustapha | Belij-Rammerstorfer, Sandra | Gilbert, Sarah | Hall, David R. | Williams, Mark A. | Paterson, Neil G. | James, William | Carroll, Miles W. | Fry, Elizabeth E. | Mongkolsapaya, Juthathip | Ren, Jingshan | Stuart, David I. | Screaton, Gavin R.
SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination. We map the impact of N501Y by structure/function analysis of a large panel of well-characterized monoclonal antibodies. B.1.1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light-chain contacts with residue 501. However, widespread escape from monoclonal antibodies or antibody responses generated by natural infection or vaccination was not observed.
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