Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines
2018
Shao, Xinxin | Li, Kangnan | Malcolmson, Steven J.
Here we report highly efficient and chemoselective azadiene–imine reductive couplings catalyzed by (Ph-BPE)Cu–H that afford anti-1,2-diamines. In all cases, reactions take place with either aldimine or ketimine electrophiles to deliver a single diastereomer of product in >95:5 er. The products’ diamines are easily differentiable, facilitating downstream synthesis.
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