Guaijaverin - a plant flavonoid as potential antiplaque agent against Streptococcus mutans
2006
Prabu, G.R. | Gnanamani, A. | Sadulla, S.
The aim of the present study was to investigate the anti-Streptococcus mutans activity and the in vitro effects of subminimal inhibitory concentrations of guaijaverin isolated from Psidium guajava Linn. on cariogenic properties of Strep. mutans. Bioautography-directed chromatographic fractionation, yield biologically active compound, quercetin-3-O-α- [smallcapital l]-arabinopyranoside (guaijaverin), from crude methanol extract of P. guajava. Growth-inhibitory activity of the compound against Strep. mutans of both clinical and type strain cultures was evaluated. The anti-Strep. mutans activity of the guaijaverin was found to be bacteriostatic, both heat and acid stable and alkali labile with the minimum inhibitory concentration (MIC) of 4 mg ml⁻¹ for MTCC 1943 and 2 mg ml⁻¹ for CLSM 001. The sub-MIC concentrations (0·0078-2 mg ml⁻¹) of the guaijaverin were evaluated for its cariogenic properties such as acid production, cell-surface hydrophobicity, sucrose-dependent adherence to glass surface and sucrose-induced aggregation of Strep. mutans. The active flavonoid compound, quercetin-3-O-α- [smallcapital l]-arabinopyranoside (guaijaverin) demonstrated high potential antiplaque agent by inhibiting the growth of the Strep. mutans. This study demonstrated the new growth-inhibitory compound guaijaverin against Strep. mutans and led to the acceptance of traditional medicine and natural products as an alternative form of health care.
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