Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys
2022
Kishida, Tomoyuki | Motokawa, Yoshiyuki | Yokoi, Ryohei | Souma, Shinji
Locomotor activity and body temperature evaluations of cynomolgus monkeys are useful to understand the effects of drugs on the central nervous system. Here, we describe a simple, inexpensive, and less invasive evaluation method using the nano tag® (KISSEI COMTEC Co., Ltd.), a small three-axis accelerometer device with a temperature sensor. Nano tags® were subcutaneously implanted in four cynomolgus monkeys that had been intraperitoneally implanted with a telemetry transmitter. Then, body temperature and locomotor activity counts were simultaneously and continuously measured by both the nano tag® and telemetry transmitter for 14 days after nano tag® implantation. The invasiveness of the implantation surgery was evaluated by recovery after surgery, and the validity of each nano tag® parameter was evaluated by comparison with the telemetry system data. Additionally, locomotor activity and body temperature changes induced by treatment with ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, were evaluated by the nano tag®. Recovery from nano tag® implantation surgery was observed at 7 days postoperative, indicating that nano tag® was less invasive than a telemetry transmitter. Both of the parameter profiles measured by nano tag® were approximately comparable to those of the telemetry system. Moreover, the nano tag® could detect ketamine-induced pharmacological changes of decreases in both parameters. The present study demonstrates that nano tag® is an effective, simple, and less invasive tool for locomotor activity and body temperature evaluations in cynomolgus monkeys. This proposed easier method could help researchers evaluate central nervous system effects in cynomolgus monkeys.
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