Effect of incorporation of serum from dogs with renal impairment on canine erythroid bone marrow cultures

Petrites-Murphy, M.B.; Pierce, K.R.; Fisher, J.W.

Effect of incorporation of serum from dogs with renal impairment on canine erythroid bone marrow cultures

1989

Petrites-Murphy, M.B. | Pierce, K.R. | Fisher, J.W.

Serum from dogs with surgically induced renal impairment was incorporated into the medium for erythroid bone marrow cultures. A significant correlation was found between serum activities of erythropoietin and numbers of erythroid colony-forming units grown in culture. Serum creatinine concentrations had no correlation, and serum parathyroid hormone activities had a negative correlation with numbers of erythroid colony-forming units that was below the level of significance. Purified 1-84 parathyroid hormone added to bone marrow cultures was found to be stimulatory to erythroid colony-forming unit growth in higher concentrations, but decreased the number of burst-forming units. Unmeasured substances in the canine serum appeared to have a greater effect on the canine erythroid bone marrow cultures than did creatinine or parathyroid hormone values.

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