Efficacy of sarolaner on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs
2019
Oliveira, Priscila Cardim de | Almeida, Gabriela Pereira Salça de | Cardoso, Jaime Dias | Tavares, Renan Bernardes | Fernandes, Júlio Israel | Correia, Thaís Ribeiro | Verocai, Guilherme Gomes | Scott, Fabio Barbour
The aim of this study was to evaluate the larval expulsion, larvicidal effect, retention rate of dead larvae and overall efficacy of sarolaner on the treatment of myiasis caused by New World screwworm Cochliomyia hominivorax in naturally infested dogs. Eight Beagle dogs received a single dose of saroalner 40 mg, with dosage ranging from 2.7 mg/kg to 3.7 mg/kg. Evaluations occurred every 15 min in the first hour, every hour for up to 6 h, and after 24 h of treatment. At 24 h post-treatment, total wound cleaning was performed, including removal and counting of remaining live and dead larvae. The animals received antibiotic, analgesic and wound cleaning support until complete wound healing. The average expulsion of the larvae was 50.9 % occurring mainly after 4 h of treatment. The larvicidal effect was 70.6 % at 6 h after treatment and 100 % at 24 h. The mean retention rate of dead larvae of sarolaner was 33.9 %, The overall efficacy was 100 %, thus making sarolaner an excellent treatment option in myiasis caused by C. hominivorax larvae in dogs.
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