Nitric Oxide (NO) and Hydrogen Sulfide (H₂S): Molecular Targets for Vascular Muscle Relaxation
2015
Sherikar, A. S. | Bhatia, M. S. | Dhavale, R. P. | Bhatia, N. M. | Choudhari, P. B.
Nitric oxide (NO) is produced in endothelial cells by nitric oxide synthase. This NO plays an important role in normal pathophysiology and homeostasis of human body. NO exerts a surfeit of biological effects in the cardiovascular system. Hydrogen sulphide (H₂S) is synthesized naturally in the body from L-cysteine mainly by the activity of two enzymes, cystathionine-γ-lyase and cystathionine-β-synthetase. The H₂S plays a vital role in vasorelaxation. Both NO and H₂S works by different mechanism to produce the effect of vascular muscle relaxation. The present review focuses on the molecular enzymatic targets for NO and H₂S for producing vascular muscle relaxation with recent advances and studies.
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