Influence of controlled dietary restriction on immunologic function and aging
1979
Weindruch, Richard H. | Kristie, James A. | Cheney, Kay E. | Walford, Roy L.
Old mice after lifelong underfeeding regimens or moderately aged mice after 4.5 months of restriction display "younger" immune systems than do age-matched, normally fed controls, as judged by response to mitogens, the mixed lymphocyte reaction, and other determinants. The immunologic effects of underfeeding, when measured quite early in life, are strain-dependent in the mouse. Diets designed to restrict the intake per week of energy (but not of protein) produce the same effects on immune response capacity in very young mice as do energy restricted, protein unbalanced regimens. Underfeeding early in life drastically dampens thymic growth and alters the timing of involution. Early restriction also produces a profound lowering of body temperature in young females. The mechanisms behind these various effects of controlled dietary restriction are poorly understood at present.
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