Low folate status as a risk factor for cervical dysplasia in Thai women
2005
Kwanbunjan, K. | Saengkar, P. | Cheeramakara, C. | Thanomsak, W. | Benjachai, W. | Laisupasin, P. | Buchachart, K. | Songmuaeng, K. | Boontaveeyuwat, N.
The relationship between folate status and the risk of cervical dysplasia was studied among Thai women. The subjects were composed of 44 women with low-grade cervical neoplasia (cervical intraepithelial neoplasm I), 70 women with high-grade cervical neoplasia (cervical intraepithelial neoplasm II, III, and carcinoma in situ), and 95 women who served as controls. The low folate status in these women showed a strong association with cervical dysplasia. Serum folate was markedly lower in both low-grade (P < .01) and high-grade cervical neoplasia cases (P < .01) compared with the control women. Using logistic regression, the odds ratio for low-grade cervical neoplasia with low serum folate level (< 19.82 nmol/L) was 6.13, whereas that of the high-grade group with the same folate level was 5.57. The findings support the contention that folate deficiency of women in this study had an increased risk of cervical change.
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