Intramolecular dehydrogenative amination of alkenes via dual organic photoredox and cobalt catalysis without a hydrogen acceptor
2022
Yu, Wan-Lei | Ren, Zi-Gang | Ma, Wei | Zheng, Haixue | Wu, Wangsuo | Xu, Peng-Fei
Direct C–H/N–H dehydrogenative coupling is a promising yet thermodynamically unfavorable transformation in the absence of a sacrificial hydrogen acceptor. Herein, a conceptually novel oxidant-free dehydrogenative amination of alkenes through a synergistic photoredox and cobalt catalysis with H₂ evolution has been achieved. With this approach, a wide range of five-membered N-heterocycles were synthesized with excellent atom-economy. The green system will address the challenges that are sensitive to traditionally oxidative conditions. Furthermore, the scope and mechanistic details of the method are discussed.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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