Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem
2016
Wang, Shucheng | Huang, Xuhu | Ge, Zemei | Wang, Xin | Li, Runtao
A metal-free process for the C-3 alkylation of imidazopyridines has been developed. Various alkylation products including alkyl ester-, cyano-, ketone- and amide-substituted imidazopyridines were prepared in good yields. With this method, a highly efficient and concise formal synthesis of alpidem (A) and zolpidem (B) has been completed.
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