Prevalence of Crimean-Congo hemorrhagic fever virus in rural areas of Guinea
2020
Naidenova, E.V. | Zakharov, K.S. | Kartashov, M.Y. | Agafonov, D.A. | Senichkina, A.M. | Magassouba, N’Faly | Nourdine, I. | Nassour, A.A. | Bah, M.B. | Kourouma, A. | Boumbali, S. | Boiro, M.Y. | Scherbakova, S.A. | Kutyrev, V.V. | Dedkov, V.G.
This article presents the results of a comprehensive survey of Guinea with the aim of assessing the burden of Crimean-Congo hemorrhagic fever virus (CCHFV) in rural areas of the country. Human serum samples (n = 2207) were studied using enzyme-linked immunosorbent assay (ELISA) for the presence of specific IgG against CCHFV. In addition, 4273 samples of partially- or fully-engorged ticks from several sources (cattle, domestic and roving dogs, and small mammals) were collected and studied using ELISA and RT-qPCR to detect CCHFV antigen and specific RNA. The data obtained show that 3.0 % of the population in rural Guinea was seropositive, without significant geographical or sexual differences. Seropositive individuals, however, were mainly in the ‘active age’ group (16–45 years old). Among ticks studied, the estimated prevalence of CCHFV was 1.3 ± 0.4 %. Five out of eight tick species studied were identified as CCHFV carriers in Guinea. Therefore, it can be assumed that the territory of Guinea is a single, continuous, natural focus of CCHFV. This identified medium intensity focus merits further study.
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