Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers
2009
Visen, Pradeep | Saraswat, Binduja | Visen, Aastha | Roller, Marc | Bily, Antoine | Mermet, Claire | He, Kan | Bai, Naisheng | Lemaire, Benoit | Lafay, Sophie | Ibarra, Alvin
Aim of the study: Fraxinus excelsior L. (Family: Oleaceae) seeds are consumed as a food, condiment, and folk medicine. The seeds are traditionally used as a potent hypoglycemic agent, but no clinical evidence exists in as to this regard. We assessed the clinical efficacy and safety of the seed extract (FraxiPure™, Naturex), containing 6.8% of nuzhenide and 5.8% of GI3 (w/w), on plasma glucose and insulin levels against glucose (50g) induced postprandial glycemia. Materials and methods: Preselected dose (1.0g) was used in a double blind, randomized, crossover, placebo (wheat bran) controlled study on 16 healthy volunteers. Each treatment was given immediately after a fasting blood glucose sample (0min). Postprandial plasma glucose levels were estimated at 0, 15, 30, 45, 60, 90 and 120min; and postprandial plasma insulin at 0, 30, 60, 90 and 120min. Results: The extract lowered the incremental postprandial plasma glucose concentration as compared to placebo at 45min (P =0.06) and 120min (P =0.07). It statistically (P =0.02) reduced the glycemic area under the blood glucose curve. The seed, also, induced a significant (P =0.002) secretion of insulin at 90min after glucose administration. However, the insulinemic area under the blood insulin curve was not different than the placebo. No adverse events were reported. Conclusions: Our findings confirm the hypoglycemic action of Fraxinus excelsior L. seed extract. These promising results, thus, encourage conducting long-term clinical studies to further evaluate the efficacy and safety of Fraxinus excelsior L. seed extract in healthy and diabetic volunteers and also to explore the possible mechanism(s) of action.
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