Profound implication of histological alterations, haematological responses and biocidal assessment of cationic amphiphiles unified with their molecular architecture
2021
Dani, Unnati | Minocheherhomji, Farida | Bahadur, Anita | Kuperkar, Ketan
The interfacial properties depicting the micellization behaviour of the cationic amphiphiles (surfactants) belonging to the class of quaternary ammonium salts varying in degree of hydrophobicity were evaluated using tensiometry, conductivity and fluorescence spectrophotometric methods at 303.15 K. The impact of the amphiphilic nature of these amphiphiles as a function of their concentration is accounted against the selective microbial strains using the well-diffusion approach. Also, its influence on the histological (shrinkage/curling of lamellae, necrosis, haemorrhage, hyperplasia of villi in gills and intestine) alterations and haematological (blood parameters) changes in fingerling of Cirrhinus mrigala (C. mrigala) offers an insight into the stern damages reported as aquatic toxicity. The lesions exhibited moderate to severe alterations that are further correlated with the semi-quantitative mean alteration value (MAV). The in vitro and in vivo findings are explained significantly in terms of amphiphilic hydrophobicity which followed the order: C₁₆TAB > C₁₂TAB. All the observed outcomes are rationalized by the structural assessment of the selected amphiphiles as specified by the computational simulation approach using density functional theory (DFT) with B3LYP method and 3-21G basis source set. This work also portrays the biodegradability of these cationic amphiphiles and their fate on the environment. Graphical abstract Molecular architecture of cationic amphiphiles integrated with their in vitro and in vivo rejoinders.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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