The Content of PPAR, LXR, and RXR and the PPAR DNA-Binding Activity in Macrophages over the Course of Inflammation in Mice
2009
Dushkin, M. I | Khoshchenko, O. M | Chasovsky, M. A | Pivovarova, E. N
The content of peroxisome proliferation activating proteins PPAR-α and PPAR-γ, liver X receptors (LXR), and retinoid X receptors (RXR) and activity of PPAR-α, PPAR-γ, and PPAR-δ binding to DNA response elements in C57Bl/6 mouse macrophages were studied during different phases of aseptic inflammation, induced by intraperitoneal injection of 50 mg/kg zymosan A. The DNA-binding activities of PPAR-α and PPAR-γ and the levels of PPAR-α, PPAR-γ, LXR, and RXR in peritoneal macrophages dropped on days 1 and 3 after zymosan injection. On days 7 and 14 the DNA-binding activity of PPAR-γ and content of PPAR-γ and LXR-β protein increased in comparison with the control, while the DNA-binding activity and content of PPAR-α in the cells remained low. Recovery of RXR protein content in macrophages was observed only on day 14 after zymosan injection.
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