Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity
2012
Donfack, Arno R.N. | Toyang, Ngeh J. | Wabo, Hippolyte K. | Tane, Pierre | Awouafack, Maurice D. | Kikuchi, Haruhisa | Tamokou, Jean D.D. | Kuiate, Jules R. | Oshima, Yoshiteru
Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1–3 and CH₂Cl₂–MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC=7.81–125μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds.
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