Soil transformation of acetochlor via glutathione conjugation
1991
Feng, P.C.C.
Acetochlor and acetochlor S-glutathione conjugate were degraded in soil with respective half-lives of 7 days and 30 min to a similar distribution of identical metabolites. Degradation of acetochlor-glutathione conjugate appears to be initiated by gamma-glutamyl transpeptidase, and the addition of gamma-glutamyl transpeptidase inhibitors effectively retarded the soil degradation of both acetochlor and its glutathione conjugate. The addition of a gamma-glutamyl transpeptidase inhibitor to the soil caused the accumulation of acetochlor-glutathione conjugate as a transient metabolite of acetochlor and thereby facilitated its detection. These results suggested that conjugation of acetochlor with glutathione is an initial pathway of metabolism in soil. Acetochlor-glutathione conjugate was further degraded in soil to acetochlor S-cysteine conjugate, which was shown to be a key intermediate in the formation of the major acidic metabolites of acetochlor in soil.
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