Distribution, antimicrobial resistance and genomic characterization of Salmonella along the pork production chain in Jiangsu, China
2022
Li, Yan | Li, Kangkang | Peng, Kai | Wang, Zhiqiang | Song, Hongqin | Li, Ruichao
Salmonella is an important foodborne pathogen that is widely distributed in foods of animal origin. Salmonella strains (n = 246) were identified from 1178 pork samples collected in Jiangsu, China. The most predominant Salmonella serovars in pork and slaughterhouse environment were S. London (49.13%, 85/173) and S. Rissen (53.42%, 39/73), respectively. A total of 13 STs were detected with ST469 dominant (33.33%, 82/246) in these isolates. Most strains were resistant to multiple drugs such as aminoglycosides (88.21%, 217/246), tetracycline (90.24%, 222/246) and florfenicol (91.87%, 226/246). Multiple antimicrobial resistance genes were identified, including that conferring resistance to aminoglycosides (strA, 64/246; strB, 60/246), β-lactam (blaTEM₋₁, 177/246), phenicols (floR, 115/246) and tetracyclines [tet(A), 216/246; tet(B), 13/246; tet(M), 51/246]. Notably, a novel IncFII(pCoo) blaNDM₋₁-positive plasmid was characterized. It is worth mentioning that this blaNDM₋₁-positive Salmonella could be successfully transferred into other Enterobacteriaceae. In addition, phylogenetic analysis indicated a high similarity between blaNDM₋₁-positive YT2-4-4 and blaNDM₋₁-positive Salmonella from human sources. To the best of our knowledge, blaNDM₋₁-carrying Salmonella of pig slaughterhouse origin was first detected. In the present study, we elaborated the distribution, drug resistance, as well as genomic characteristics of Salmonella in the pork production chain, providing valuable baseline data for food safety risk assessment.
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